Original Article

IJMDC. 2020; 4(3): 700-705

Circadian misalignment effect on HbA1c among patients with diabetes

Authors: Hyder Osman Mirghani, Sultan Saleh Albalawi, Hosam Hadi Awaji, Abdulrahman Mohammed Naji Alharbi, Ahmed Marwan Alamrani, Saeed Ali Ibrahim Alzahrani, Saud Abdulrahman Saad Alghamdi, Nawaf Musallam Salem Albalawi, Sultanah Faisal Alghabban.

ABSTRACT

Background: Several research studies have been reporting an association between circadian rhythm and glucose levels. This study was aimed to calculate the prevalence of circadian misalignment in patients with diabetes, to identify the association between sleep parameters and glycemic control, and to investigate its effect on glycemic control, as assessed by hemoglobin a1c (HbA1c). Methodology: A cross-sectional study was carried out in the Diabetes Outpatient Clinic at the Diabetes Center, King Fahad Specialist Hospital, Tabuk city, Saudi Arabia. A convenient sample includes adult patients of 18 years or older with either type 1 or type 2 diabetes and residents of Tabuk city. Data collection was carried out through a face-to-face interview using a structured questionnaire. Results: This study included 187 diabetic patients. About one-fourth of them (27.3%) reported skipping breakfast three times or more. The bedtime lag between the weekdays and weekend was more than 2 hours in about half (51.3%) of them. Significantly, there was a higher median HbA1c in patients with a higher number (≥3) of skipped breakfast (8.0 vs. 7.0, respectively, p = 0.006). There was a significant negative association between the calculated bedtime lag between the weekdays and weekend and HbA1c (r = −0.16, p = 0.030). Conclusion: The findings of this study indicated an association between a circadian misalignment in the form of skipping breakfast ≥3 times/week, bedtime lag between the weekdays and weekends, and poor glycemic control in adult diabetic patients. These findings are expected to contribute to the prevention and risk reduction of complications in diabetic patients.

Keywords:
Circadian misalignment, HbA1c, diabetes


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Circadian misalignment effect on HbA1c among patients with diabetes


Authors
Hyder Osman Mirghani
Department of Internal Medicine and Endocrine, Medical College, University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Sultan Saleh Albalawi
Resident, Medical College, University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Hosam Hadi Awaji
Intern, Medical College, University of Tabuk, Tabuk, Saudi Arabia
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Abdulrahman Mohammed Naji Alharbi
Intern, Medical College, University of Tabuk, Tabuk, Saudi Arabia
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Ahmed Marwan Alamrani
Intern, Medical College, University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Saeed Ali Ibrahim Alzahrani
Intern, Medical College, University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Saud Abdulrahman Saad Alghamdi
Intern, Medical College, University of Tabuk, Tabuk, Saudi Arabia
PubMed articlesGoogle scholar articles

Nawaf Musallam Salem Albalawi
Intern, Medical College, University of Tabuk, Tabuk, Saudi Arabia
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Sultanah Faisal Alghabban
Intern, Medical College, University of Tabuk, Tabuk, Saudi Arabia
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Correspondence to:
. Sultan Saleh Albalawi, Resident, Medical College, University of Tabuk, Tabuk, Saudi Arabia.; s.s.s.alblawi@gmail.com

Publication history
Received 30 Dec 2019
Accepted 16 Jan 2020
Published online 16 Jan 2020
Published in print 25 Feb 2020

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Pubmed Style

Mirghani HO, Albalawi SS, Awaji HH, Alharbi AMN, Alamrani AM, Alzahrani SAI, Alghamdi SAS, Albalawi NMS, Alghabban SF. Circadian misalignment effect on HbA1c among patients with diabetes. IJMDC. 2020; 4(3): 700-705. doi:10.24911/IJMDC.51-1577741348


Web Style

Mirghani HO, Albalawi SS, Awaji HH, Alharbi AMN, Alamrani AM, Alzahrani SAI, Alghamdi SAS, Albalawi NMS, Alghabban SF. Circadian misalignment effect on HbA1c among patients with diabetes. http://www.ijmdc.com/?mno=80020 [Access: March 29, 2020]. doi:10.24911/IJMDC.51-1577741348


AMA (American Medical Association) Style

Mirghani HO, Albalawi SS, Awaji HH, Alharbi AMN, Alamrani AM, Alzahrani SAI, Alghamdi SAS, Albalawi NMS, Alghabban SF. Circadian misalignment effect on HbA1c among patients with diabetes. IJMDC. 2020; 4(3): 700-705. doi:10.24911/IJMDC.51-1577741348


Vancouver/ICMJE Style

Mirghani HO, Albalawi SS, Awaji HH, Alharbi AMN, Alamrani AM, Alzahrani SAI, Alghamdi SAS, Albalawi NMS, Alghabban SF. Circadian misalignment effect on HbA1c among patients with diabetes. IJMDC. (2020), [cited March 29, 2020]; 4(3): 700-705. doi:10.24911/IJMDC.51-1577741348


Harvard Style

Mirghani, H. O., Albalawi, . S. S., Awaji, . H. H., Alharbi, . A. M. N., Alamrani, . A. M., Alzahrani, . S. A. I., Alghamdi, . S. A. S., Albalawi, . N. M. S. & Alghabban, . S. F. (2020) Circadian misalignment effect on HbA1c among patients with diabetes. IJMDC, 4 (3), 700-705. doi:10.24911/IJMDC.51-1577741348


Turabian Style

Mirghani, Hyder Osman, Sultan Saleh Albalawi, Hosam Hadi Awaji, Abdulrahman Mohammed Naji Alharbi, Ahmed Marwan Alamrani, Saeed Ali Ibrahim Alzahrani, Saud Abdulrahman Saad Alghamdi, Nawaf Musallam Salem Albalawi, and Sultanah Faisal Alghabban. 2020. Circadian misalignment effect on HbA1c among patients with diabetes. International Journal of Medicine in Developing Countries, 4 (3), 700-705. doi:10.24911/IJMDC.51-1577741348


Chicago Style

Mirghani, Hyder Osman, Sultan Saleh Albalawi, Hosam Hadi Awaji, Abdulrahman Mohammed Naji Alharbi, Ahmed Marwan Alamrani, Saeed Ali Ibrahim Alzahrani, Saud Abdulrahman Saad Alghamdi, Nawaf Musallam Salem Albalawi, and Sultanah Faisal Alghabban. "Circadian misalignment effect on HbA1c among patients with diabetes." International Journal of Medicine in Developing Countries 4 (2020), 700-705. doi:10.24911/IJMDC.51-1577741348


MLA (The Modern Language Association) Style

Mirghani, Hyder Osman, Sultan Saleh Albalawi, Hosam Hadi Awaji, Abdulrahman Mohammed Naji Alharbi, Ahmed Marwan Alamrani, Saeed Ali Ibrahim Alzahrani, Saud Abdulrahman Saad Alghamdi, Nawaf Musallam Salem Albalawi, and Sultanah Faisal Alghabban. "Circadian misalignment effect on HbA1c among patients with diabetes." International Journal of Medicine in Developing Countries 4.3 (2020), 700-705. Print. doi:10.24911/IJMDC.51-1577741348


APA (American Psychological Association) Style

Mirghani, H. O., Albalawi, . S. S., Awaji, . H. H., Alharbi, . A. M. N., Alamrani, . A. M., Alzahrani, . S. A. I., Alghamdi, . S. A. S., Albalawi, . N. M. S. & Alghabban, . S. F. (2020) Circadian misalignment effect on HbA1c among patients with diabetes. International Journal of Medicine in Developing Countries, 4 (3), 700-705. doi:10.24911/IJMDC.51-1577741348


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