E-ISSN 1658-7820
 

Original Article

Online Publishing Date:
23 / 01 / 2020

 


L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study

Osama Safdar, Ghazal Jambi, Omar Asaad, Lujain Hassan, Lujain AlDahlawi, Abdalrashid F. Halawani, Mohammed Jamjoom, Bahaa Shaikhoon, Ahmad Azhar, Zaher F. Zaher, Shatha Albokhari, Mohammed Shalaby.


Cited By: 1

Abstract
Background: Patients with end-stage renal failure resort to different forms of renal replacement therapy, including peritoneal dialysis, hemodialysis, and renal transplantation. Hemodialysis patients often have reduced L-carnitine levels predisposing them to different musculoskeletal myopathies. This study aims to evaluate the beneficial circumstances of administering L-carnitine to dialyzed patients regarding improvements in the values of Parathyroid hormone (PTH), Calcium (Ca), Hemoglobin (HB), and Vitamin D levels (Vit D).
Methodology: This experimental study was conducted in a non-randomized manner among a sample size of seven pediatric patients under 18 years of age undergoing dialysis with low L-carnitine levels in King Abdul-Aziz University Hospital, throughout 6 to 10 months. L-carnitine was administered at a fixed dose of 50 mg/kg. Our focus was directed on the levels PTH, Ca2+, Hb, VitD, and PO4.
Results: The mean of phosphate was not significant with p-value 0.499. The mean of PTH level before administering the drug was 134.26 and after administering the drug it was found 57.41. This decrease was statistically significant with p-value 0.028. The mean of Ca was not significant with p-value 0.735. The mean of HB is not significant with p-value 0.499. The mean of Vit D was not significant (p-value 0.237).
Conclusion: The only significant statistical result was involving PTH. Decreasing the level of PTH had several advantages most importantly it led to reduction of bone resorption; therefore, maintaining bone density and decreasing the likelihood of developing degenerative bone diseases.

Key words: Pediatric, hemodialysis, L-carnitine


 
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How to Cite this Article
Pubmed Style

Safdar O, Jambi G, Asaad O, Hassan L, AlDahlawi L, Halawani AF, Jamjoom M, Shaikhoon B, Azhar A, Zaher ZF, Albokhari S, Shalaby M. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. IJMDC. 2020; 4(3): 612-619. doi:10.24911/IJMDC.51-1574511938


Web Style

Safdar O, Jambi G, Asaad O, Hassan L, AlDahlawi L, Halawani AF, Jamjoom M, Shaikhoon B, Azhar A, Zaher ZF, Albokhari S, Shalaby M. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. https://www.ijmdc.com/?mno=74994 [Access: March 26, 2024]. doi:10.24911/IJMDC.51-1574511938


AMA (American Medical Association) Style

Safdar O, Jambi G, Asaad O, Hassan L, AlDahlawi L, Halawani AF, Jamjoom M, Shaikhoon B, Azhar A, Zaher ZF, Albokhari S, Shalaby M. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. IJMDC. 2020; 4(3): 612-619. doi:10.24911/IJMDC.51-1574511938



Vancouver/ICMJE Style

Safdar O, Jambi G, Asaad O, Hassan L, AlDahlawi L, Halawani AF, Jamjoom M, Shaikhoon B, Azhar A, Zaher ZF, Albokhari S, Shalaby M. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. IJMDC. (2020), [cited March 26, 2024]; 4(3): 612-619. doi:10.24911/IJMDC.51-1574511938



Harvard Style

Safdar, O., Jambi, . G., Asaad, . O., Hassan, . L., AlDahlawi, . L., Halawani, . A. F., Jamjoom, . M., Shaikhoon, . B., Azhar, . A., Zaher, . Z. F., Albokhari, . S. & Shalaby, . M. (2020) L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. IJMDC, 4 (3), 612-619. doi:10.24911/IJMDC.51-1574511938



Turabian Style

Safdar, Osama, Ghazal Jambi, Omar Asaad, Lujain Hassan, Lujain AlDahlawi, Abdalrashid F. Halawani, Mohammed Jamjoom, Bahaa Shaikhoon, Ahmad Azhar, Zaher F. Zaher, Shatha Albokhari, and Mohammed Shalaby. 2020. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. International Journal of Medicine in Developing Countries, 4 (3), 612-619. doi:10.24911/IJMDC.51-1574511938



Chicago Style

Safdar, Osama, Ghazal Jambi, Omar Asaad, Lujain Hassan, Lujain AlDahlawi, Abdalrashid F. Halawani, Mohammed Jamjoom, Bahaa Shaikhoon, Ahmad Azhar, Zaher F. Zaher, Shatha Albokhari, and Mohammed Shalaby. "L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study." International Journal of Medicine in Developing Countries 4 (2020), 612-619. doi:10.24911/IJMDC.51-1574511938



MLA (The Modern Language Association) Style

Safdar, Osama, Ghazal Jambi, Omar Asaad, Lujain Hassan, Lujain AlDahlawi, Abdalrashid F. Halawani, Mohammed Jamjoom, Bahaa Shaikhoon, Ahmad Azhar, Zaher F. Zaher, Shatha Albokhari, and Mohammed Shalaby. "L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study." International Journal of Medicine in Developing Countries 4.3 (2020), 612-619. Print. doi:10.24911/IJMDC.51-1574511938



APA (American Psychological Association) Style

Safdar, O., Jambi, . G., Asaad, . O., Hassan, . L., AlDahlawi, . L., Halawani, . A. F., Jamjoom, . M., Shaikhoon, . B., Azhar, . A., Zaher, . Z. F., Albokhari, . S. & Shalaby, . M. (2020) L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. International Journal of Medicine in Developing Countries, 4 (3), 612-619. doi:10.24911/IJMDC.51-1574511938





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