Original Article

IJMDC. 2020; 4(3): 612-619

L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study

Authors: Osama Safdar, Ghazal Jambi, Omar Asaad, Lujain Hassan, Lujain AlDahlawi, Abdalrashid F. Halawani, Mohammed Jamjoom, Bahaa Shaikhoon, Ahmad Azhar, Zaher F. Zaher, Shatha Albokhari, Mohammed Shalaby.

ABSTRACT

Background: Patients with end-stage renal failure resort to different forms of renal replacement therapy, including peritoneal dialysis, hemodialysis, and renal transplantation. Hemodialysis patients often have reduced L-carnitine levels predisposing them to different musculoskeletal myopathies. This study aims to evaluate the beneficial circumstances of administering L-carnitine to dialyzed patients regarding improvements in the values of Parathyroid hormone (PTH), Calcium (Ca), Hemoglobin (HB), and Vitamin D levels (Vit D). Methodology: This experimental study was conducted in a non-randomized manner among a sample size of seven pediatric patients under 18 years of age undergoing dialysis with low L-carnitine levels in King Abdul-Aziz University Hospital, throughout 6 to 10 months. L-carnitine was administered at a fixed dose of 50 mg/kg. Our focus was directed on the levels PTH, Ca2+, Hb, VitD, and PO4. Results: The mean of phosphate was not significant with p-value 0.499. The mean of PTH level before administering the drug was 134.26 and after administering the drug it was found 57.41. This decrease was statistically significant with p-value 0.028. The mean of Ca was not significant with p-value 0.735. The mean of HB is not significant with p-value 0.499. The mean of Vit D was not significant (p-value 0.237). Conclusion: The only significant statistical result was involving PTH. Decreasing the level of PTH had several advantages most importantly it led to reduction of bone resorption; therefore, maintaining bone density and decreasing the likelihood of developing degenerative bone diseases.

Keywords:
Pediatric, hemodialysis, L-carnitine


View PDF
L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study


Authors
Osama Safdar
Pediatric Nephrology Center of Excellence, Faculty of Medicine, King Abdulaziz University, Alsulimania, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Ghazal Jambi
Faculty of Medicine, King Abdulaziz University, Alsulimania, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Omar Asaad
Faculty of Medicine, King Abdulaziz University, Alsulimania, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Lujain Hassan
Faculty of Medicine, King Abdulaziz University, Alsulimania, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Lujain AlDahlawi
Faculty of Medicine, King Abdulaziz University, Alsulimania, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Abdalrashid F Halawani
Faculty of Medicine, King Abdulaziz University, Alsulimania, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Mohammed Jamjoom
Faculty of Medicine, King Abdulaziz University, Alsulimania, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Bahaa Shaikhoon
Faculty of Medicine, King Abdulaziz University, Alsulimania, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Ahmad Azhar
Pediatric Department, Faculty of Medicine, King Abdulaziz University, Alsulimania, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Zaher F Zaher
Pediatric Department, Faculty of Medicine, King Abdulaziz University, Alsulimania, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Shatha Albokhari
Pediatric Department, Faculty of Medicine, King Abdulaziz University, Alsulimania, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Mohammed Shalaby
Pediatric Nephrology Center of Excellence, Faculty of Medicine, King Abdulaziz University, Alsulimania, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles


Correspondence to:
. Ghazal Jambi, Faculty of Medicine, King Abdulaziz University, Alsulimania, Jeddah, Saudi Arabia.; safderosama@hotmail.com

Publication history
Received 23 Nov 2019
Published in print 25 Feb 2020

How to cite this article?

Export to EndNote Export to refMan

Pubmed Style

Safdar O, Jambi G, Asaad O, Hassan L, AlDahlawi L, Halawani AF, Jamjoom M, Shaikhoon B, Azhar A, Zaher ZF, Albokhari S, Shalaby M. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. IJMDC. 2020; 4(3): 612-619. doi:10.24911/IJMDC.51-1574511938


Web Style

Safdar O, Jambi G, Asaad O, Hassan L, AlDahlawi L, Halawani AF, Jamjoom M, Shaikhoon B, Azhar A, Zaher ZF, Albokhari S, Shalaby M. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. http://www.ijmdc.com/?mno=74994 [Access: March 29, 2020]. doi:10.24911/IJMDC.51-1574511938


AMA (American Medical Association) Style

Safdar O, Jambi G, Asaad O, Hassan L, AlDahlawi L, Halawani AF, Jamjoom M, Shaikhoon B, Azhar A, Zaher ZF, Albokhari S, Shalaby M. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. IJMDC. 2020; 4(3): 612-619. doi:10.24911/IJMDC.51-1574511938


Vancouver/ICMJE Style

Safdar O, Jambi G, Asaad O, Hassan L, AlDahlawi L, Halawani AF, Jamjoom M, Shaikhoon B, Azhar A, Zaher ZF, Albokhari S, Shalaby M. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. IJMDC. (2020), [cited March 29, 2020]; 4(3): 612-619. doi:10.24911/IJMDC.51-1574511938


Harvard Style

Safdar, O., Jambi, . G., Asaad, . O., Hassan, . L., AlDahlawi, . L., Halawani, . A. F., Jamjoom, . M., Shaikhoon, . B., Azhar, . A., Zaher, . Z. F., Albokhari, . S. & Shalaby, . M. (2020) L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. IJMDC, 4 (3), 612-619. doi:10.24911/IJMDC.51-1574511938


Turabian Style

Safdar, Osama, Ghazal Jambi, Omar Asaad, Lujain Hassan, Lujain AlDahlawi, Abdalrashid F. Halawani, Mohammed Jamjoom, Bahaa Shaikhoon, Ahmad Azhar, Zaher F. Zaher, Shatha Albokhari, and Mohammed Shalaby. 2020. L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. International Journal of Medicine in Developing Countries, 4 (3), 612-619. doi:10.24911/IJMDC.51-1574511938


Chicago Style

Safdar, Osama, Ghazal Jambi, Omar Asaad, Lujain Hassan, Lujain AlDahlawi, Abdalrashid F. Halawani, Mohammed Jamjoom, Bahaa Shaikhoon, Ahmad Azhar, Zaher F. Zaher, Shatha Albokhari, and Mohammed Shalaby. "L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study." International Journal of Medicine in Developing Countries 4 (2020), 612-619. doi:10.24911/IJMDC.51-1574511938


MLA (The Modern Language Association) Style

Safdar, Osama, Ghazal Jambi, Omar Asaad, Lujain Hassan, Lujain AlDahlawi, Abdalrashid F. Halawani, Mohammed Jamjoom, Bahaa Shaikhoon, Ahmad Azhar, Zaher F. Zaher, Shatha Albokhari, and Mohammed Shalaby. "L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study." International Journal of Medicine in Developing Countries 4.3 (2020), 612-619. Print. doi:10.24911/IJMDC.51-1574511938


APA (American Psychological Association) Style

Safdar, O., Jambi, . G., Asaad, . O., Hassan, . L., AlDahlawi, . L., Halawani, . A. F., Jamjoom, . M., Shaikhoon, . B., Azhar, . A., Zaher, . Z. F., Albokhari, . S. & Shalaby, . M. (2020) L-Carnitine effect on bone disease in hemodialysis pediatric patients in KAU Hospital, Jeddah Saudi Arabia: an experimental non-randomized study. International Journal of Medicine in Developing Countries, 4 (3), 612-619. doi:10.24911/IJMDC.51-1574511938


Share this article

Click the icon of the social media platform on which you would like to share this article.

Article Statistics

Viewed: 707
Downloaded: 101

Request permissions

If you wish to reuse any part or all of this article please contact the copyright holder, contact@ejmcr.com.

Copyright © 2018 Discover Publishing Group. All Rights Reserved.