Original Article

IJMDC. 2019; 3(8): 716-725

Prevalence and determinants of advanced-stage breast cancer in Jeddah tertiary hospitals, Saudi Arabia

Authors: Norah Alotaibi, Razan Alosaimy, Wedyan Al-Mushaddak, Manahil Nouri.

ABSTRACT

Background: Breast cancer ranks second most commonly diagnosed cancer worldwide, with approximately 12% among all cancers; while in women it stands as the most prevalent cancer in 154 countries and the leading cause of cancer death in 103 countries. The stage of breast cancer at diagnosis is an outstanding prognostic factor of treatment efficacy and survival, as well as a determinant factor of local and metastatic recurrence. Advanced-stage breast cancer (AS-BC) is associated with lower survival rates compared to early diagnosed cases. The present study aimed at estimating the prevalence of advanced-stage breast cancer (AS-BC) among newly diagnosed female subjects and to identify the associated factors and predictors of the disease. Methodology: A retrospective chart review was conducted in three tertiary hospitals in Jeddah, Saudi Arabia, including patients with breast cancer, who were diagnosed and followed up in the participating centers during the period October 2013 to October 2018. Data were collected in a standardized fashion using a semi-structured datasheet. Results: A total of 824 women were included in the study. Further, AS-BC rate was found lower among patients with a family history of breast cancer and or personal history of benign breast disease; while it was higher among those with a history of exposure to ionization radiation or other comorbidities, notably diabetes and hypertension. Significant lifestyle factors included a sedentary lifestyle, higher weight and body mass index (BMI). Among all statistically significant factors, educational level (postgraduate, OR=0.17, p=0.006) and exposure to ionization radiation (OR=2.50, p<0.001) were the only independent factors of AS-BC. Conclusion: Advanced-stage accounts for two-thirds of the primary breast cancer cases, which is remarkably higher than the reported international literature and contrasting with the locally implemented screening and prevention programs. The identification of socioeconomic factors of AS-BC should guide the adaptation of care offered and communication strategies in order to improve the attendance to systematic screening programs among the most deprived groups.

Keywords:
Breast cancer, advanced stage, late diagnosis, screening, prevention.


View PDF
Prevalence and determinants of advanced-stage breast cancer in Jeddah tertiary hospitals, Saudi Arabia


Authors
Norah Alotaibi
Joint program of Family Medicine, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Razan Alosaimy
Joint program of Family Medicine, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Wedyan Al-Mushaddak
Joint program of Family Medicine, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles

Manahil Nouri
Saudi Board for Community and Preventive Medicine, Jeddah, Saudi Arabia
PubMed articlesGoogle scholar articles


Correspondence to:
. Joint program of Family Medicine, Jeddah, Saudi Arabia;; dr-nora101@hotmail.com

Publication history
Received 11 Apr 2019
Accepted 23 Apr 2019
Published in print 21 May 2019

How to cite this article?

Export to EndNote Export to refMan

Pubmed Style

Alotaibi N, Alosaimy R, Al-Mushaddak W, Nouri M. Prevalence and determinants of advanced-stage breast cancer in Jeddah tertiary hospitals, Saudi Arabia. IJMDC. 2019; 3(8): 716-725. doi:10.24911/IJMDC.51-1555003245


Web Style

Alotaibi N, Alosaimy R, Al-Mushaddak W, Nouri M. Prevalence and determinants of advanced-stage breast cancer in Jeddah tertiary hospitals, Saudi Arabia. http://www.ijmdc.com/?mno=43036 [Access: August 20, 2019]. doi:10.24911/IJMDC.51-1555003245


AMA (American Medical Association) Style

Alotaibi N, Alosaimy R, Al-Mushaddak W, Nouri M. Prevalence and determinants of advanced-stage breast cancer in Jeddah tertiary hospitals, Saudi Arabia. IJMDC. 2019; 3(8): 716-725. doi:10.24911/IJMDC.51-1555003245


Vancouver/ICMJE Style

Alotaibi N, Alosaimy R, Al-Mushaddak W, Nouri M. Prevalence and determinants of advanced-stage breast cancer in Jeddah tertiary hospitals, Saudi Arabia. IJMDC. (2019), [cited August 20, 2019]; 3(8): 716-725. doi:10.24911/IJMDC.51-1555003245


Harvard Style

Alotaibi, N., Alosaimy, . R., Al-Mushaddak, . W. & Nouri, . M. (2019) Prevalence and determinants of advanced-stage breast cancer in Jeddah tertiary hospitals, Saudi Arabia. IJMDC, 3 (8), 716-725. doi:10.24911/IJMDC.51-1555003245


Turabian Style

Alotaibi, Norah, Razan Alosaimy, Wedyan Al-Mushaddak, and Manahil Nouri. 2019. Prevalence and determinants of advanced-stage breast cancer in Jeddah tertiary hospitals, Saudi Arabia. International Journal of Medicine in Developing Countries, 3 (8), 716-725. doi:10.24911/IJMDC.51-1555003245


Chicago Style

Alotaibi, Norah, Razan Alosaimy, Wedyan Al-Mushaddak, and Manahil Nouri. "Prevalence and determinants of advanced-stage breast cancer in Jeddah tertiary hospitals, Saudi Arabia." International Journal of Medicine in Developing Countries 3 (2019), 716-725. doi:10.24911/IJMDC.51-1555003245


MLA (The Modern Language Association) Style

Alotaibi, Norah, Razan Alosaimy, Wedyan Al-Mushaddak, and Manahil Nouri. "Prevalence and determinants of advanced-stage breast cancer in Jeddah tertiary hospitals, Saudi Arabia." International Journal of Medicine in Developing Countries 3.8 (2019), 716-725. Print. doi:10.24911/IJMDC.51-1555003245


APA (American Psychological Association) Style

Alotaibi, N., Alosaimy, . R., Al-Mushaddak, . W. & Nouri, . M. (2019) Prevalence and determinants of advanced-stage breast cancer in Jeddah tertiary hospitals, Saudi Arabia. International Journal of Medicine in Developing Countries, 3 (8), 716-725. doi:10.24911/IJMDC.51-1555003245


Share this article

Click the icon of the social media platform on which you would like to share this article.

Article Statistics

Viewed: 191
Downloaded: 0
Cited: 0

Request permissions

If you wish to reuse any part or all of this article please contact the copyright holder, contact@ejmcr.com.

Copyright © 2018 Discover Publishing Group. All Rights Reserved.