Original Article

IJMDC. 2019; 3(9): 26-29

The impact of changing branded statins into generic drugs at the National Guard Hospital in Riyadh, Saudi Arabia

Authors: Abdulaziz Dahham N Alshalan, Mohammed Fawzan A Almuhraj, Faris Awadh G Alotaibi, Mohammed Aldegiri, Hind Almodaimegh.

ABSTRACT

Background: Health care expenditure remains one of the major issues to tackle for all countries around the globe. To overcome this, some hospitals involve in the process of changing medications from the brand named drugs to their generic counterparts. However, the question that remains among the physicians and the patient group is whether these generic drugs could compromise the effectiveness and safety. Thus the objective of the present study is to explore the impact of changing statins from their brand to generic counterparts on the level of low-density lipoprotein (LDL) in patients with hyperlipidemia. Methodology A retrospective chart review was conducted at King Abdulaziz Cardiac Centre, National Guard Hospital in Riyadh, Saudi Arabia during the period of January 2018 to May 2018. A total of 876 patients were made to switch from brand to generic statin. The lipid profile (total cholesterol, LDL-cholesterol, High-density lipoprotein (HDL)-cholesterol, triglycerides) analyzed during the year 2016 (the drug switching period) was compared with the lipid profile results recorded in 2017. Other labs tests were also investigated to check for variations. Results: A total of 500 patients were analyzed during the study. Significance difference was found on comparison of the mean values for: LDL (2.5 mmol/l vs 2.2 mmol/l; p = 0.000), HDL (1.0 mmol/l vs 0.90 mmol/l; p = 0.006), cholesterol (4.2 mmol/l vs 3.8 mmol/l; p = 0.000), and triglycerides (1.7 mmol/l vs 2.0 mmol/l; p = 0.425). Conclusion: The patients who switched from brand named drugs to generic named drugs had better outcome according to the lab results. Our findings support the hospital's efforts in switching statin from brand (Lipitor«) to generic statin and maintaining the efficacy of the drug.

Keywords:
Statins, generic drugs, LDL


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The impact of changing branded statins into generic drugs at the National Guard Hospital in Riyadh, Saudi Arabia


Authors
Abdulaziz Dahham N Alshalan
Al-Maarefa University, Ad Diriyah, Saudi Arabia
PubMed articlesGoogle scholar articles

Mohammed Fawzan A Almuhraj
Al-Maarefa University, Ad Diriyah, Saudi Arabia
PubMed articlesGoogle scholar articles

Faris Awadh G Alotaibi
Al-Maarefa University, Ad Diriyah, Saudi Arabia
PubMed articlesGoogle scholar articles

Mohammed Aldegiri
King Abdulaziz Medical City, Riyadh, Saudi Arabia
PubMed articlesGoogle scholar articles

Hind Almodaimegh
King Abdulaziz Medical City, Riyadh, Saudi Arabia
PubMed articlesGoogle scholar articles


Correspondence to:
. Al-Maarefa University, Ad Diriyah, Saudi Arabia; md-f111@hotmail.com

Publication history
Received 20 Feb 2019
Accepted 13 May 2019
Published online 26 May 2019
Published in print 15 Aug 2019

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Pubmed Style

Alshalan ADN, Almuhraj MFA, Alotaibi FAG, Aldegiri M, Almodaimegh H. The impact of changing branded statins into generic drugs at the National Guard Hospital in Riyadh, Saudi Arabia. IJMDC. 2019; 3(9): 26-29. doi:10.24911/IJMDC.51-1549965220


Web Style

Alshalan ADN, Almuhraj MFA, Alotaibi FAG, Aldegiri M, Almodaimegh H. The impact of changing branded statins into generic drugs at the National Guard Hospital in Riyadh, Saudi Arabia. http://www.ijmdc.com/?mno=31115 [Access: September 23, 2019]. doi:10.24911/IJMDC.51-1549965220


AMA (American Medical Association) Style

Alshalan ADN, Almuhraj MFA, Alotaibi FAG, Aldegiri M, Almodaimegh H. The impact of changing branded statins into generic drugs at the National Guard Hospital in Riyadh, Saudi Arabia. IJMDC. 2019; 3(9): 26-29. doi:10.24911/IJMDC.51-1549965220


Vancouver/ICMJE Style

Alshalan ADN, Almuhraj MFA, Alotaibi FAG, Aldegiri M, Almodaimegh H. The impact of changing branded statins into generic drugs at the National Guard Hospital in Riyadh, Saudi Arabia. IJMDC. (2019), [cited September 23, 2019]; 3(9): 26-29. doi:10.24911/IJMDC.51-1549965220


Harvard Style

Alshalan, A. D. N., Almuhraj, . M. F. A., Alotaibi, . F. A. G., Aldegiri, . M. & Almodaimegh, . H. (2019) The impact of changing branded statins into generic drugs at the National Guard Hospital in Riyadh, Saudi Arabia. IJMDC, 3 (9), 26-29. doi:10.24911/IJMDC.51-1549965220


Turabian Style

Alshalan, Abdulaziz Dahham N, Mohammed Fawzan A Almuhraj, Faris Awadh G Alotaibi, Mohammed Aldegiri, and Hind Almodaimegh. 2019. The impact of changing branded statins into generic drugs at the National Guard Hospital in Riyadh, Saudi Arabia. International Journal of Medicine in Developing Countries, 3 (9), 26-29. doi:10.24911/IJMDC.51-1549965220


Chicago Style

Alshalan, Abdulaziz Dahham N, Mohammed Fawzan A Almuhraj, Faris Awadh G Alotaibi, Mohammed Aldegiri, and Hind Almodaimegh. "The impact of changing branded statins into generic drugs at the National Guard Hospital in Riyadh, Saudi Arabia." International Journal of Medicine in Developing Countries 3 (2019), 26-29. doi:10.24911/IJMDC.51-1549965220


MLA (The Modern Language Association) Style

Alshalan, Abdulaziz Dahham N, Mohammed Fawzan A Almuhraj, Faris Awadh G Alotaibi, Mohammed Aldegiri, and Hind Almodaimegh. "The impact of changing branded statins into generic drugs at the National Guard Hospital in Riyadh, Saudi Arabia." International Journal of Medicine in Developing Countries 3.9 (2019), 26-29. Print. doi:10.24911/IJMDC.51-1549965220


APA (American Psychological Association) Style

Alshalan, A. D. N., Almuhraj, . M. F. A., Alotaibi, . F. A. G., Aldegiri, . M. & Almodaimegh, . H. (2019) The impact of changing branded statins into generic drugs at the National Guard Hospital in Riyadh, Saudi Arabia. International Journal of Medicine in Developing Countries, 3 (9), 26-29. doi:10.24911/IJMDC.51-1549965220


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