IJMDC. 2019; 3(1): 99-103

Adenosine deaminase activity in subjects with normal and insufficient liver function.

Authors: Seraj Ahmed Khan, Rajendra Kumar Chaudhari, Sarita Lamichane, Madhab Lamsal.

ABSTRACT

Background: Adenosine Deaminase (ADA), a nonspecific marker for cellular immunity, is raised in diseases eliciting a cell-mediated immune response. High serum ADA activities were observed in patients with different liver diseases. This study was aimed to determine the association of serum ADA and transaminases levels in liver disease patients and normal control. Methodology: In this comparative cross-sectional study 80 subjects, 40 with liver disease and 40 without liver disease were enrolled. Blood samples were drawn and analysis was done. Liver function profile was done by Autoanalyzer and ADA activity was measured by Giusti and Galanti's colorimetric method. Independent t-test and Mann Whitney U test for the association; Pearsonís correlation and Spearmanís Rho for correlation study. Multiple linear regression model was used for the independent association of the variable with ADA. P<0.05 set as statistically significant. Results: Based on liver function tests, subjects were divided into Group 1 (normal liver function) and Group 2 (altered liver function) with 40 individual in each group and mean age was 40.0Ī16.5 years and 42.4Ī16.3 years respectively. Total bilirubin, direct bilirubin, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and ADA was higher in subjects with liver insufficiency (group 2) and was statistically significant. ADA was significantly correlated with albumin, AST, ALT, and ALP in subjects with normal liver function whereas no such pattern was noticed in patients with liver insufficiency. Conclusion: This study demonstrates that the serum ADA activity is predominantly elevated in subjects with altered liver function and highlight its role in diagnosis and monitoring the clinical status of the patients with liver insufficiency.

Keywords:
Adenosine deaminase, aspartate transaminase, alanine transaminase, alkaline phosphatase, liver function test


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Adenosine deaminase activity in subjects with normal and insufficient liver function.


Authors
Seraj Ahmed Khan
B.P. Koirala Institute of Health Sciences, Nepal
PubMed articlesGoogle scholar articles

Rajendra Kumar Chaudhari
B. P. Koirala Institute of Health Sciences, Nepal
PubMed articlesGoogle scholar articles

Sarita Lamichane
B. P. Koirala Institute of Health Sciences, Nepal
PubMed articlesGoogle scholar articles

Madhab Lamsal
B. P. Koirala Institute of Health Sciences, Nepal
PubMed articlesGoogle scholar articles


Correspondence to:
Seraj Ahmed Khan. Seraj Ahmed Khan, B.P. Koirala Institute of Health Sciences, Nepal; drserajkhan@gmail.com

Publication history
Published online 01 Jan 1970
Received 30 May 2018
Revised 20 Sep 2018
Accepted 28 Sep 2018
Published in print 01 Feb 2019

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Pubmed Style

Khan SA, Chaudhari RK, Lamichane S, Lamsal M. Adenosine deaminase activity in subjects with normal and insufficient liver function.. IJMDC. 2019; 3(1): 99-103. doi:10.24911/IJMDC.51-1527660074


Web Style

Khan SA, Chaudhari RK, Lamichane S, Lamsal M. Adenosine deaminase activity in subjects with normal and insufficient liver function.. http://www.ijmdc.com/?mno=300602 [Access: February 16, 2019]. doi:10.24911/IJMDC.51-1527660074


AMA (American Medical Association) Style

Khan SA, Chaudhari RK, Lamichane S, Lamsal M. Adenosine deaminase activity in subjects with normal and insufficient liver function.. IJMDC. 2019; 3(1): 99-103. doi:10.24911/IJMDC.51-1527660074


Vancouver/ICMJE Style

Khan SA, Chaudhari RK, Lamichane S, Lamsal M. Adenosine deaminase activity in subjects with normal and insufficient liver function.. IJMDC. (2019), [cited February 16, 2019]; 3(1): 99-103. doi:10.24911/IJMDC.51-1527660074


Harvard Style

Khan, S. A., Chaudhari, . R. K., Lamichane, . S. & Lamsal, . M. (2019) Adenosine deaminase activity in subjects with normal and insufficient liver function.. IJMDC, 3 (1), 99-103. doi:10.24911/IJMDC.51-1527660074


Turabian Style

Khan, Seraj Ahmed, Rajendra Kumar Chaudhari, Sarita Lamichane, and Madhab Lamsal. 2019. Adenosine deaminase activity in subjects with normal and insufficient liver function.. International Journal of Medicine in Developing Countries, 3 (1), 99-103. doi:10.24911/IJMDC.51-1527660074


Chicago Style

Khan, Seraj Ahmed, Rajendra Kumar Chaudhari, Sarita Lamichane, and Madhab Lamsal. "Adenosine deaminase activity in subjects with normal and insufficient liver function.." International Journal of Medicine in Developing Countries 3 (2019), 99-103. doi:10.24911/IJMDC.51-1527660074


MLA (The Modern Language Association) Style

Khan, Seraj Ahmed, Rajendra Kumar Chaudhari, Sarita Lamichane, and Madhab Lamsal. "Adenosine deaminase activity in subjects with normal and insufficient liver function.." International Journal of Medicine in Developing Countries 3.1 (2019), 99-103. Print. doi:10.24911/IJMDC.51-1527660074


APA (American Psychological Association) Style

Khan, S. A., Chaudhari, . R. K., Lamichane, . S. & Lamsal, . M. (2019) Adenosine deaminase activity in subjects with normal and insufficient liver function.. International Journal of Medicine in Developing Countries, 3 (1), 99-103. doi:10.24911/IJMDC.51-1527660074


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