Original Article

IJMDC. 2019; 3(1): 43-49

Comparison of serum level of Anti-Mullerian hormone in fertile and infertile women in South West Nigeria

Authors: Elizebeth Olufunke Oke, Oluwaseyi Felix Oke, Abdukareem Afolabi Salawu, Joel Olufunminiyi Akande, Wulemotu Taiwo Oloyede, Rafiat Adeola Karem, Kola Musliudin Owonikoko, Adeolu Oladayo Akinboro, Paul Sunday Ogunro.

ABSTRACT

Background: Serum anti-Mullerian hormone (AMH) is solely produced in the human ovary by the granulosa cells and is considered as a better biomarker both quantitatively and qualitatively in the evaluation of ovarian reserve compared with FSH, LH, and Estradiol. This study was designed to compare serum AMH level in fertile and infertile women in South West Nigeria. Methodology: Sixty-four participants who presented for infertility treatment were consecutively recruited into the study, while another Sixty-Four participants who presented at family planning clinics for contraception and women at the Infant Welfare clinic who brought their children for immunization as controls. Results: The mean value of serum AMH in the subjects was 2.66 4.23 ng/ml which is significantly lower (p < 0.001) compared with (10.32 5.85 ng/ml) in the control group. The FSH was also significantly elevated (p = 0.028) in the subjects (13.00 18.03 UI/l) compared with the controls (7.96 2.1 UI/l). The mean serum Estradiol of (60.30 76.05 pg/ml) for the subject was significantly elevated (p = 0.003) compared with control (30.37 18.55 pg/ml). There was a negative correlation between serum level of AMH and age of subjects (r = −0.032), and duration of infertility (r = −0.155) and were not statistically significant. Conclusion: In this study, the serum AMH level was significantly lower in the infertile women than in the fertile women. AMH could be considered as a marker for assessing the ovarian reserve in women at any time, as it is cycle independent compared with the other hormones like FSH.

Keywords:
AMH, FSH, infertility, menstrual cycle


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Comparison of serum level of Anti-Mullerian hormone in fertile and infertile women in South West Nigeria


Authors
Elizebeth Olufunke Oke
Department of Chemical Pathology, Bowen University Iwo, Nigeria
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Oluwaseyi Felix Oke
Department of Obstetrics and Gynaecology, King Faisal Hospital, Kigali Rwanda
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Abdukareem Afolabi Salawu
Department of Chemical Pathology, Lautech Teaching Hospital Ogbomoso, Nigeria
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Joel Olufunminiyi Akande
Department of Chemical Pathology, Bowen University, Iwo, Nigeria
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Wulemotu Taiwo Oloyede
Department of Chemical Pathology, Lautech Teaching Hospital Ogbomoso, Nigeria
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Rafiat Adeola Karem
Department of Chemical Pathology, Lautech Teaching Hospital Ogbomoso, Nigeria
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Kola Musliudin Owonikoko
Department of Obstetrics and Gynaecology, Lautech Teaching Hospital Ogbomoso, Nigeria
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Adeolu Oladayo Akinboro
Department of Medicine, Lautech Teaching Hospital Ogbomoso, Nigeria
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Paul Sunday Ogunro
Department of Chemical Pathology, Lautech Teaching Hospital Ogbomoso, Nigeria
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Correspondence to:
. ; prophyjoe30@yahoo.com

Publication history
Published online 01 Jan 1970
Received 22 Nov 2018
Accepted 15 Dec 2018
Published in print 01 Feb 2019

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Pubmed Style

Oke EO, Oke OF, Salawu AA, Akande JO, Oloyede WT, Karem RA, Owonikoko KM, Akinboro AO, Ogunro PS. Comparison of serum level of Anti-Mullerian hormone in fertile and infertile women in South West Nigeria. IJMDC. 2019; 3(1): 43-49. doi:10.24911/IJMDC.51-1542882156


Web Style

Oke EO, Oke OF, Salawu AA, Akande JO, Oloyede WT, Karem RA, Owonikoko KM, Akinboro AO, Ogunro PS. Comparison of serum level of Anti-Mullerian hormone in fertile and infertile women in South West Nigeria. http://www.ijmdc.com/?mno=18403 [Access: July 23, 2019]. doi:10.24911/IJMDC.51-1542882156


AMA (American Medical Association) Style

Oke EO, Oke OF, Salawu AA, Akande JO, Oloyede WT, Karem RA, Owonikoko KM, Akinboro AO, Ogunro PS. Comparison of serum level of Anti-Mullerian hormone in fertile and infertile women in South West Nigeria. IJMDC. 2019; 3(1): 43-49. doi:10.24911/IJMDC.51-1542882156


Vancouver/ICMJE Style

Oke EO, Oke OF, Salawu AA, Akande JO, Oloyede WT, Karem RA, Owonikoko KM, Akinboro AO, Ogunro PS. Comparison of serum level of Anti-Mullerian hormone in fertile and infertile women in South West Nigeria. IJMDC. (2019), [cited July 23, 2019]; 3(1): 43-49. doi:10.24911/IJMDC.51-1542882156


Harvard Style

Oke, E. O., Oke, . O. F., Salawu, . A. A., Akande, . J. O., Oloyede, . W. T., Karem, . R. A., Owonikoko, . K. M., Akinboro, . A. O. & Ogunro, . P. S. (2019) Comparison of serum level of Anti-Mullerian hormone in fertile and infertile women in South West Nigeria. IJMDC, 3 (1), 43-49. doi:10.24911/IJMDC.51-1542882156


Turabian Style

Oke, Elizebeth Olufunke, Oluwaseyi Felix Oke, Abdukareem Afolabi Salawu, Joel Olufunminiyi Akande, Wulemotu Taiwo Oloyede, Rafiat Adeola Karem, Kola Musliudin Owonikoko, Adeolu Oladayo Akinboro, and Paul Sunday Ogunro. 2019. Comparison of serum level of Anti-Mullerian hormone in fertile and infertile women in South West Nigeria. International Journal of Medicine in Developing Countries, 3 (1), 43-49. doi:10.24911/IJMDC.51-1542882156


Chicago Style

Oke, Elizebeth Olufunke, Oluwaseyi Felix Oke, Abdukareem Afolabi Salawu, Joel Olufunminiyi Akande, Wulemotu Taiwo Oloyede, Rafiat Adeola Karem, Kola Musliudin Owonikoko, Adeolu Oladayo Akinboro, and Paul Sunday Ogunro. "Comparison of serum level of Anti-Mullerian hormone in fertile and infertile women in South West Nigeria." International Journal of Medicine in Developing Countries 3 (2019), 43-49. doi:10.24911/IJMDC.51-1542882156


MLA (The Modern Language Association) Style

Oke, Elizebeth Olufunke, Oluwaseyi Felix Oke, Abdukareem Afolabi Salawu, Joel Olufunminiyi Akande, Wulemotu Taiwo Oloyede, Rafiat Adeola Karem, Kola Musliudin Owonikoko, Adeolu Oladayo Akinboro, and Paul Sunday Ogunro. "Comparison of serum level of Anti-Mullerian hormone in fertile and infertile women in South West Nigeria." International Journal of Medicine in Developing Countries 3.1 (2019), 43-49. Print. doi:10.24911/IJMDC.51-1542882156


APA (American Psychological Association) Style

Oke, E. O., Oke, . O. F., Salawu, . A. A., Akande, . J. O., Oloyede, . W. T., Karem, . R. A., Owonikoko, . K. M., Akinboro, . A. O. & Ogunro, . P. S. (2019) Comparison of serum level of Anti-Mullerian hormone in fertile and infertile women in South West Nigeria. International Journal of Medicine in Developing Countries, 3 (1), 43-49. doi:10.24911/IJMDC.51-1542882156


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