Original Article

IJMDC. 2020; 4(7): 1062-1069

A pilot study on the association of KCNJ11 genetic polymorphism (rs5215 Val250Ile) with Type 2 diabetes mellitus among the Saudi Arabian population (Eastern province)

Authors: Aldanah Mohammed Althwanay, Leenah Nabil Turkistani, Bothaynah Abdulrahman Alarfaj, Ebtisam Ali Alhwaider, Fatimah Samer Albagshi.

ABSTRACT

Background: Diabetes is a chronic metabolic disorder. Single nucleotide polymorphisms in the KCNJ11 gene have shown to play a role in the development of Type 2 diabetes mellitus (T2DM). The present pilot study was aimed at evaluating the relationship between KCNJ11 polymorphism (rs5215) with T2DM susceptibility in the eastern province among the Saudi Arabian population. Methodology: A case-control study was conducted on 49 confirmed T2DM patients and 39 control subjects from the family and community center in Dammam. The T2DM diagnosis was based on the American Diabetic Association criteria. The peripheral blood was collected by venipuncture. The genomic deoxyribonucleic acid was extracted and the KCNJ11 gene rs5215 polymorphism was genotyped by TaqMan chemistry using real-time polymerase chain reaction. Statistical tests were performed using statistical package for the social sciences ver19 software and the results were counted as significant if the p-value is <0.05. Results: Anthropological parameters, such as weight and body mass index, in the patients and control groups were significantly different (p = 0.012 and p = 0.006); respectively. The minor allele C of rs5215 was overrepresented in T2DM patient (0.24) compared to controls (0.15), the association did not reach statistical significance. The rs5215 genotype (p = 0.443) and allele (p = 0.139) showed an insignificant relationship with the T2DM. Conclusion: This study is the first of its kind to report the frequency and to assess the relationship between rs5215 of KCNJ11 with T2DM in the eastern province of the Saudi Arabian population. The rs5215 of the KCNJ11 gene showed no significant association with the T2DM in this population.

Keywords:
ATP-sensitive potassium channels, T2DM, single nucleotide polymorphism, rs5215, KCNJ11


View PDF
A pilot study on the association of KCNJ11 genetic polymorphism (rs5215 Val250Ile) with Type 2 diabetes mellitus among the Saudi Arabian population (Eastern province)


Authors
Aldanah Mohammed Althwanay
Physician Intern at King Fahad Hospital of the University (KFHU), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia
PubMed articlesGoogle scholar articles

Leenah Nabil Turkistani
Physician Intern at King Fahad Hospital of the University (KFHU), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia
PubMed articlesGoogle scholar articles

Bothaynah Abdulrahman Alarfaj
Physician Intern at King Fahad Hospital of the University (KFHU), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia
PubMed articlesGoogle scholar articles

Ebtisam Ali Alhwaider
Physician Intern at King Fahad Hospital of the University (KFHU), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia
PubMed articlesGoogle scholar articles

Fatimah Samer Albagshi
Physician Intern at King Fahad Hospital of the University (KFHU), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia
PubMed articlesGoogle scholar articles


Correspondence to:
. Aldanah Mohammed Althwanay, Physician Intern at King Fahad Hospital of the University (KFHU), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia.; dana_althwanay@hotmail.com

Publication history
Received 20 Apr 2020
Accepted 15 May 2020
Published online 23 Jun 2020
Published in print 10 Jul 2020

How to cite this article?

Export to EndNote Export to refMan

Pubmed Style

Althwanay AM, Turkistani LN, Alarfaj BA, Alhwaider EA, Albagshi FS. A pilot study on the association of KCNJ11 genetic polymorphism (rs5215 Val250Ile) with Type 2 diabetes mellitus among the Saudi Arabian population (Eastern province). IJMDC. 2020; 4(7): 1062-1069. doi:10.24911/IJMDC.51-1587353314


Web Style

Althwanay AM, Turkistani LN, Alarfaj BA, Alhwaider EA, Albagshi FS. A pilot study on the association of KCNJ11 genetic polymorphism (rs5215 Val250Ile) with Type 2 diabetes mellitus among the Saudi Arabian population (Eastern province). http://www.ijmdc.com/?mno=100594 [Access: August 04, 2020]. doi:10.24911/IJMDC.51-1587353314


AMA (American Medical Association) Style

Althwanay AM, Turkistani LN, Alarfaj BA, Alhwaider EA, Albagshi FS. A pilot study on the association of KCNJ11 genetic polymorphism (rs5215 Val250Ile) with Type 2 diabetes mellitus among the Saudi Arabian population (Eastern province). IJMDC. 2020; 4(7): 1062-1069. doi:10.24911/IJMDC.51-1587353314


Vancouver/ICMJE Style

Althwanay AM, Turkistani LN, Alarfaj BA, Alhwaider EA, Albagshi FS. A pilot study on the association of KCNJ11 genetic polymorphism (rs5215 Val250Ile) with Type 2 diabetes mellitus among the Saudi Arabian population (Eastern province). IJMDC. (2020), [cited August 04, 2020]; 4(7): 1062-1069. doi:10.24911/IJMDC.51-1587353314


Harvard Style

Althwanay, A. M., Turkistani, . L. N., Alarfaj, . B. A., Alhwaider, . E. A. & Albagshi, . F. S. (2020) A pilot study on the association of KCNJ11 genetic polymorphism (rs5215 Val250Ile) with Type 2 diabetes mellitus among the Saudi Arabian population (Eastern province). IJMDC, 4 (7), 1062-1069. doi:10.24911/IJMDC.51-1587353314


Turabian Style

Althwanay, Aldanah Mohammed, Leenah Nabil Turkistani, Bothaynah Abdulrahman Alarfaj, Ebtisam Ali Alhwaider, and Fatimah Samer Albagshi. 2020. A pilot study on the association of KCNJ11 genetic polymorphism (rs5215 Val250Ile) with Type 2 diabetes mellitus among the Saudi Arabian population (Eastern province). International Journal of Medicine in Developing Countries, 4 (7), 1062-1069. doi:10.24911/IJMDC.51-1587353314


Chicago Style

Althwanay, Aldanah Mohammed, Leenah Nabil Turkistani, Bothaynah Abdulrahman Alarfaj, Ebtisam Ali Alhwaider, and Fatimah Samer Albagshi. "A pilot study on the association of KCNJ11 genetic polymorphism (rs5215 Val250Ile) with Type 2 diabetes mellitus among the Saudi Arabian population (Eastern province)." International Journal of Medicine in Developing Countries 4 (2020), 1062-1069. doi:10.24911/IJMDC.51-1587353314


MLA (The Modern Language Association) Style

Althwanay, Aldanah Mohammed, Leenah Nabil Turkistani, Bothaynah Abdulrahman Alarfaj, Ebtisam Ali Alhwaider, and Fatimah Samer Albagshi. "A pilot study on the association of KCNJ11 genetic polymorphism (rs5215 Val250Ile) with Type 2 diabetes mellitus among the Saudi Arabian population (Eastern province)." International Journal of Medicine in Developing Countries 4.7 (2020), 1062-1069. Print. doi:10.24911/IJMDC.51-1587353314


APA (American Psychological Association) Style

Althwanay, A. M., Turkistani, . L. N., Alarfaj, . B. A., Alhwaider, . E. A. & Albagshi, . F. S. (2020) A pilot study on the association of KCNJ11 genetic polymorphism (rs5215 Val250Ile) with Type 2 diabetes mellitus among the Saudi Arabian population (Eastern province). International Journal of Medicine in Developing Countries, 4 (7), 1062-1069. doi:10.24911/IJMDC.51-1587353314


Share this article

Click the icon of the social media platform on which you would like to share this article.

Article Statistics

Request permissions

If you wish to reuse any part or all of this article please contact the copyright holder, contact@ejmcr.com.

Copyright © 2018 Discover Publishing Group. All Rights Reserved.